|
|
N-acetyl-9-O-acetylneuraminic_acid + H2O <=> N-acetylneuraminate + H+ + acetate
|
3.1.1.53
sialate O-acetylesterase
3.1.1.6
acetylesterase
|
–
–
|
|
|
BRENDA:
BR11721
KEGG:
R01810;
R08601
MetaCyc:
RXN-13182
|
|
|
|
N-acetylneuraminate + acetyl-CoA <=> N-acetyl-4-O-acetylneuraminate + CoA
|
2.3.1.44
N-acetylneuraminate 4-O-acetyltransferase
|
–
|
|
|
BRENDA:
BR44045
KEGG:
R01806
MetaCyc:
2.3.1.44-RXN
|
|
|
|
N-acetylneuraminate + acetyl-CoA <=> N-acetyl-9-O-acetylneuraminic_acid + CoA
|
2.3.1.45
N-acetylneuraminate 7-O(or 9-O)-acetyltransferase
|
–
|
|
|
BRENDA:
BR44046
KEGG:
R01808
MetaCyc:
RXN-7864
|
|
|
|
alpha-D-N-acetylneuraminic_acid <=> N-acetylneuraminate
|
5.1.3.24
N-acetylneuraminate epimerase
|
–
|
|
|
BRENDA:
BR49787
KEGG:
R09797
MetaCyc:
RXN0-5329
|
|
|
|
N-acetylneuraminate + acetyl-CoA <=> N-acetyl-7-O-acetylneuraminate + CoA
|
2.3.1.45
N-acetylneuraminate 7-O(or 9-O)-acetyltransferase
|
–
|
|
|
BRENDA:
BS386192;
BS407090
KEGG:
R01807
MetaCyc:
2.3.1.45-RXN
|
|
|
|
N-acetylneuraminate + CTP <=> CMP-N-acetylneuraminate + diphosphate
|
2.7.7.43
N-acylneuraminate cytidylyltransferase
2.7.7.92
3-deoxy-D-glycero-D-galacto-nonulopyranosonate cytidylyltransferase
|
–
–
|
BMK
|
|
BRENDA:
BS388407
KEGG:
R01117
MetaCyc:
RXN-9990
SABIO-RK:
1376
|
|
|
|
N-acetyl-4-O-acetylneuraminate + H2O <=> N-acetylneuraminate + H+ + acetate
|
3.1.1.53
sialate O-acetylesterase
|
–
|
|
|
BRENDA:
BS405925
KEGG:
R08600
MetaCyc:
RXN-13181
|
|
|
|
N-acetylneuraminate <=> N-acetyl-D-mannosamine + pyruvate
|
4.1.3.3
N-acetylneuraminate lyase
|
–
|
BMK
|
|
BRENDA:
BR3374
KEGG:
R01811
MetaCyc:
ACNEULY-RXN
SABIO-RK:
7666
|
|
|
|
phosphoenolpyruvate + N-acetyl-D-mannosamine + H2O <=> phosphate + N-acetylneuraminate
|
2.5.1.56
N-acetylneuraminate synthase
|
–
|
BK
|
|
BRENDA:
BR47462
KEGG:
R01804
SABIO-RK:
1890
|
|
|
|
GD1a + H2O <=> GM1 + N-acetylneuraminate
|
3.2.1.18
exo-alpha-sialidase
|
–
|
|
|
BRENDA:
BS370960
KEGG:
R04650;
R06253
SABIO-RK:
4312
|
|
|
|
N-acetylneuraminate_9-phosphate + H2O <=> N-acetylneuraminate + phosphate
|
3.1.3.103
3-deoxy-D-glycero-D-galacto-nonulopyranosonate 9-phosphatase
3.1.3.29
N-acylneuraminate-9-phosphatase
|
–
–
|
K
|
|
BRENDA:
BS437718
KEGG:
R01805
SABIO-RK:
1891
|
|
|
|
ganglioside_GM3 + H2O <=> N-acetylneuraminate + beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide
|
3.2.1.18
exo-alpha-sialidase
|
–
|
|
|
BRENDA:
BS447547
KEGG:
R03491;
R05999
SABIO-RK:
3283
|
|
|
|
S-adenosyl-L-methionine + N-acetylneuraminate <=> S-adenosyl-L-homocysteine + N-acetyl-8-O-methyl-neuraminate
|
2.1.1.B3
|
–
|
|
|
BRENDA:
BR48878
SABIO-RK:
12677
|
|
|
|
4-methylumbelliferyl-alpha-D-N-acetylneuraminic_acid + H2O <=> 4-Methylumbelliferone + N-acetylneuraminate
|
3.2.1.18
exo-alpha-sialidase
|
–
|
|
|
BRENDA:
BS115510
SABIO-RK:
9695
|
|
|
|
3'-sialyllactose + H2O <=> N-acetylneuraminate + lactose
|
3.2.1.18
exo-alpha-sialidase
|
–
|
|
|
BRENDA:
BS370854;
BS452727
SABIO-RK:
13050;
13085
|
|
|
|
N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-1,4-beta-D-glucosyl-N-acylsphingosine + H2O <=> GalNAc-beta-1,4-Gal-beta-1,4-Glc-beta-1,1-Cer + N-acetylneuraminate
|
3.2.1.18
exo-alpha-sialidase
|
–
|
|
|
KEGG:
R04634;
R06012
SABIO-RK:
4296
|
|
|
|
ganglioside_GT1b + H2O <=> GD1b + N-acetylneuraminate
|
3.2.1.18
exo-alpha-sialidase
|
–
|
|
|
KEGG:
R05117;
R05998
SABIO-RK:
4738
|
|
|
|
N-acetylneuraminate + 2 ferricytochrome_b5 + O2 + 2 H+ <=> N-glycolylneuraminate + 2 ferricytochrome_b5 + H2O
|
1.14.18.2
CMP-N-acetylneuraminate monooxygenase
|
–
|
K
|
|
KEGG:
R01803
|
|
|
|
galactosylceramide + N-acetylneuraminate <=> GM4 + H2O
|
3.2.1.18
exo-alpha-sialidase
|
–
|
K
|
|
KEGG:
R04018
|
|
|
|
ganglioside_GT1b + N-acetylneuraminate <=> GQ1 + H2O
|
3.2.1.18
exo-alpha-sialidase
|
–
|
|
|
KEGG:
R05115
|
|
|
|
ganglioside_GT1b + N-acetylneuraminate <=> GQ1b + H2O
|
3.2.1.18
exo-alpha-sialidase
|
–
|
|
|
KEGG:
R05996
|
|
|
|
galactosylceramide + N-acetylneuraminate <=> GM4 + H2O
|
3.2.1.18
exo-alpha-sialidase
|
–
|
|
|
KEGG:
R06147
|
|
|
|
alpha-N-acetylneuraminate-(2rarr8)-alpha-N-acetylneuraminate-glycoside + H2O <=> N-acetyl-alpha-D-neuraminate_glycoside + N-acetylneuraminate
|
3.2.1.129
endo-alpha-sialidase
|
–
|
|
|
MetaCyc:
3.2.1.129-RXN
|
|
|
|
sialyloligosaccharides + H2O <=> oligosaccharides + N-acetylneuraminate
|
3.2.1.18
exo-alpha-sialidase
|
–
|
|
|
MetaCyc:
3.2.1.18-RXN
|
|
|
|
phosphoenolpyruvate + N-acetyl-D-mannosamine + H2O <=> N-acetylneuraminate + phosphate
|
2.5.1.56
N-acetylneuraminate synthase
|
–
|
M
|
|
MetaCyc:
N-ACETYLNEURAMINATE-SYNTHASE-RXN
|
|
|
|
N-acetylneuraminate <=> N-acetyl-beta-D-mannosamine + pyruvate
|
4.1.3.3
N-acetylneuraminate lyase
|
–
|
|
|
MetaCyc:
RXN-15313
|
|
|
|
N-acetylneuraminate + H+ <=> N-acetylneuraminate + H+
|
not assigned
|
–
|
|
|
MetaCyc:
RXN-15314
|
|
|
|
N-acetylneuraminate <=> N-acetylneuraminate
|
not assigned
|
–
|
|
|
MetaCyc:
RXN-15315
|
|
|
|
N-acetyl-beta-neuraminate_9-phosphate + H2O <=> N-acetylneuraminate + phosphate
|
3.1.3.29
N-acylneuraminate-9-phosphatase
|
–
|
M
|
|
MetaCyc:
RXN-9989
|
|
|
|
N-acetylneuraminate <=> N-acetylneuraminate
|
not assigned
|
–
|
|
|
MetaCyc:
RXN0-0
|
|
|
|
N-acetylneuraminate + H+ <=> N-acetylneuraminate + H+
|
not assigned
|
–
|
|
|
MetaCyc:
TRANS-RXN-25
|
|
|
|
N-acetylneuraminic_acid-alpha-2,3-lactose + H2O <=> N-acetylneuraminate + lactose
|
3.2.1.18
exo-alpha-sialidase
|
–
|
|
|
BRENDA:
BS115523
|
|
|
|
3''-siallyllactose + H2O <=> N-acetylneuraminate + lactose
|
3.2.1.18
exo-alpha-sialidase
|
–
|
|
|
BRENDA:
BS446657
|
|
|
|
CDP + N-acetylneuraminate <=> phosphate + CMP-N-acetylneuraminate
|
2.7.7.43
N-acylneuraminate cytidylyltransferase
|
–
|
|
|
BRENDA:
BS359892
|
|
|
|
UDP + N-acetylneuraminate <=> phosphate + UMP-N-acetylneuraminate
|
2.7.7.43
N-acylneuraminate cytidylyltransferase
|
–
|
|
|
BRENDA:
BS359893
|
|
|
|
acetyl-CoA + N-acetylneuraminate <=> CoA + 5-N-acetyl-8-O-acetyl-neuraminate
|
2.3.1.45
N-acetylneuraminate 7-O(or 9-O)-acetyltransferase
|
–
|
|
|
BRENDA:
BS386193
|
|
|
|
acetyl-CoA + N-acetylneuraminate <=> CoA + O-(acetyl)-Neu5Ac
|
2.3.1.136
polysialic-acid O-acetyltransferase
|
–
|
|
|
BRENDA:
BS396309
|
|
|
|
4-methylumbelliferyl_D-N-acetylneuraminyl-alpha-(2->3)-D-galactopyranoside + H2O <=> 4-Methylumbelliferone + N-acetylneuraminate + 4-methylumbelliferyl_alpha-D-galactoside
|
3.2.1.18
exo-alpha-sialidase
|
–
|
|
|
BRENDA:
BS418300
|
|
|
|
colominic_acid + H2O <=> N-acetylneuraminate + lactose
|
3.2.1.18
exo-alpha-sialidase
|
–
|
|
|
BRENDA:
BR19208
|
|
|
|
Neu5Ac(2-3)-alpha-lactose + H2O <=> N-acetylneuraminate + lactose
|
3.2.1.18
exo-alpha-sialidase
|
–
|
|
|
BRENDA:
BS382411
|
|
|
|
N-acetyl-O-9-acetylneuraminate + H2O <=> N-acetylneuraminate + acetate
|
3.1.1.53
sialate O-acetylesterase
|
–
|
|
|
BRENDA:
BS415692
|
|
|
|
acetyl-CoA + N-acetylneuraminate <=> N-acetyl-9-O-acetylneuraminic_acid
|
2.3.1.45
N-acetylneuraminate 7-O(or 9-O)-acetyltransferase
|
–
|
|
|
BRENDA:
BS454256
|
|
|
|
4-O-acetyl-sialic_acid + H2O <=> N-acetylneuraminate + acetate
|
3.1.1.53
sialate O-acetylesterase
|
–
|
|
|
BRENDA:
BS411381
|
|
|
|
CTP + N-acetylneuraminate <=> diphosphate + CMP-N-acylneuraminate
|
2.7.7.43
N-acylneuraminate cytidylyltransferase
|
–
|
|
|
BRENDA:
BR50678
|
|
|
|
N[(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosyl)onate]-3-methylpyridinium + H2O <=> N-acetylneuraminate + 3-methylpyridine
|
3.2.1.18
exo-alpha-sialidase
|
–
|
|
|
BRENDA:
BS374053
|
|
|
|
N[(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosyl)onate]pyridinium + H2O <=> N-acetylneuraminate + Pyridine
|
3.2.1.18
exo-alpha-sialidase
|
–
|
|
|
BRENDA:
BS374055
|
|
|
|
N[(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosyl)onate]-4-methylpyridinium + H2O <=> N-acetylneuraminate + 4-methylpyridine
|
3.2.1.18
exo-alpha-sialidase
|
–
|
|
|
BRENDA:
BS374054
|
|
|
|
ganglioside_GD3 + H2O <=> N-acetylneuraminate + ganglioside_GM3
|
3.2.1.18
exo-alpha-sialidase
|
–
|
|
|
BRENDA:
BS447546
|
|
|
|
(trifluoromethyl)umbelliferyl_alpha-sialoside + H2O <=> 7-hydroxy-4-trifluoromethylcoumarin + N-acetylneuraminate
|
3.2.1.18
exo-alpha-sialidase
|
–
|
|
|
BRENDA:
BS403159
|
|
|
|
2-(3-methoxyphenyl)-N-acetylneuraminic_acid + H2O <=> 3-methoxyphenol + N-acetylneuraminate
|
3.2.1.18
exo-alpha-sialidase
|
–
|
|
|
BRENDA:
BS115531
|
|
|
|
5-acetylneuraminic_acid-(alpha2,6)Galbeta-4-nitrophenol + H2O <=> N-acetylneuraminate + 4-nitrophenyl_beta-D-galactopyranoside
|
3.2.1.18
exo-alpha-sialidase
|
–
|
|
|
BRENDA:
BS418963
|
|
|
|
N[(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosyl)onate]-3,4-dimethylpyridinium + H2O <=> N-acetylneuraminate + 3,4-dimethylpyridine
|
3.2.1.18
exo-alpha-sialidase
|
–
|
|
|
BRENDA:
BS374052
|
|
|
|
polysialic_acid + H2O <=> N-acetylneuraminate
|
3.2.1.18
exo-alpha-sialidase
|
–
|
|
|
BRENDA:
BS374395
|
|
|
|
2-deoxy-2,3-dehydro-N-acetylneuraminic_acid + H2O <=> N-acetylneuraminate
|
3.2.1.18
exo-alpha-sialidase
|
–
|
|
|
BRENDA:
BS403522
|
|
|
|
Candida_albicans_cells + H2O <=> desialylated_Candida_albicans_cells + N-acetylneuraminate
|
3.2.1.18
exo-alpha-sialidase
|
–
|
|
|
BRENDA:
BS372614
|
|
|
|
6''-sialyllactose + H2O <=> N-acetylneuraminate + lactose
|
3.2.1.18
exo-alpha-sialidase
|
–
|
|
|
BRENDA:
BS429828
|
|
|
|
N-acetylneuraminic_acid-alpha-2,6-galactose + H2O <=> N-acetylneuraminate + D-galactose
|
3.2.1.18
exo-alpha-sialidase
|
–
|
|
|
BRENDA:
BS115524
|
|
|
|
Neu5Acalpha-4-nitrophenyl + H2O <=> 4-nitrophenol + N-acetylneuraminate
|
3.2.1.18
exo-alpha-sialidase
|
–
|
|
|
BRENDA:
BS429775
|
|
|
|
4-nitrophenyl_alpha-sialoside + H2O <=> 4-nitrophenol + N-acetylneuraminate
|
3.2.1.18
exo-alpha-sialidase
|
–
|
|
|
BRENDA:
BS403930
|
|
|
|
colomic_acid + H2O <=> N-acetylneuraminate + lactose
|
3.2.1.18
exo-alpha-sialidase
|
–
|
|
|
BRENDA:
BS372750
|
|
|
|
ganglioside_GM3(Neu5Ac) + H2O <=> desialylated_ganglioside_GM3 + N-acetylneuraminate
|
3.2.1.18
exo-alpha-sialidase
|
–
|
|
|
BRENDA:
BS373254
|
|
|
|
ganglioside_GM3(Neu5Gc) + H2O <=> desialylated_ganglioside_GM3 + N-acetylneuraminate
|
3.2.1.18
exo-alpha-sialidase
|
–
|
|
|
BRENDA:
BS373255
|
|
|
|
ganglioside_IV3-alpha-Neu5Ac-nLc4Cer + H2O <=> paragloboside + N-acetylneuraminate
|
3.2.1.18
exo-alpha-sialidase
|
–
|
|
|
BRENDA:
BS373257
|
|
|
|
ganglioside_VI3-alpha-Neu5Ac-nLc6Cer + H2O <=> desialylated_ganglioside_nLc6Cer + N-acetylneuraminate
|
3.2.1.18
exo-alpha-sialidase
|
–
|
|
|
BRENDA:
BS373258
|
|
|
|
Neu5Gcalpha-(2-8)-Neu5Ac + H2O <=> N-glycolylneuraminate + N-acetylneuraminate
|
3.2.1.18
exo-alpha-sialidase
|
–
|
|
|
BRENDA:
BS374031
|
|
|
|
sialyl-alpha-(2-8)-sialic_acid + H2O <=> N-acetylneuraminate
|
3.2.1.18
exo-alpha-sialidase
|
–
|
|
|
BRENDA:
BS374637
|
|
|
|
Neu5Ac(2-6)-alpha-lactose + H2O <=> N-acetylneuraminate + lactose
|
3.2.1.18
exo-alpha-sialidase
|
–
|
|
|
BRENDA:
BS382412
|
|
|
|
alpha-N-acetylneuraminyl-2,3-beta-D-(1-O-(4-nitrophenyl)-galactopyranose) + H2O <=> N-acetylneuraminate + 4-nitrophenyl_beta-D-galactopyranoside
|
3.2.1.18
exo-alpha-sialidase
|
–
|
|
|
BRENDA:
BS418962
|
|
|
|
N-acetylneuraminic_acid-alpha-2,6-lactose + H2O <=> N-acetylneuraminate + lactose
|
3.2.1.18
exo-alpha-sialidase
|
–
|
|
|
BRENDA:
BS115522
|
|
|
|
NeuAcalpha2-3Galbeta1-4GlcNAc + H2O <=> N-acetylneuraminate + N-acetyllactosamine
|
3.2.1.18
exo-alpha-sialidase
|
–
|
|
|
BRENDA:
BS430554
|
|
|
|
CMP-N-acetylneuraminate + N-acetylneuraminate <=> CMP + alpha-N-acetylneuraminyl-(2->8)-beta-N-acetylneuraminate
|
2.4.99.8
alpha-N-acetylneuraminate alpha-2,8-sialyltransferase
|
–
|
|
|
BRENDA:
BS423155
|
|
|
|
5-bromo-4-chloro-3-indolyl-alpha-D-N-acetylneuraminic_acid + H2O <=> 5-bromo-4-chloro-3-indoxol + N-acetylneuraminate
|
3.2.1.18
exo-alpha-sialidase
|
–
|
|
|
BRENDA:
BS429825
|
|
|
|
H2O + GT1 <=> GD1 + N-acetylneuraminate
|
3.2.1.18
exo-alpha-sialidase
|
–
|
|
|
SABIO-RK:
14344
|
|
|
|
alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-D-glucosylceramide + H2O <=> N-acetylneuraminate + Gal-beta1->4GlcNAc-beta1->3Gal-beta1->4Glc-beta1->1''Cer
|
3.2.1.18
exo-alpha-sialidase
|
–
|
|
|
SABIO-RK:
13770
|
|
|
|
H2O + Neu5Ac-DSPE <=> N-acetylneuraminate + DSPE
|
3.2.1.18
exo-alpha-sialidase
|
–
|
|
|
SABIO-RK:
13669
|
|
|
|
GM1 + H2O <=> N-acetylneuraminate + gibberellin_1
|
3.2.1.18
exo-alpha-sialidase
|
–
|
|
|
SABIO-RK:
13643
|
|
|
|
GD1b + H2O <=> N-acetylneuraminate + GM1
|
3.2.1.18
exo-alpha-sialidase
|
–
|
|
|
SABIO-RK:
13525
|
|